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Certain genes play a major role in the development of prostate cancer


Many people with prostate cancer have a specific gene mutation
Prostate cancer is a serious illness that causes many people worldwide to die. In Germany, about every third out of 100 people die from this form of cancer. Researchers have now found that inherited genes play a greater role in the development of prostate cancer than previously thought. Around twelve percent of the sick men seem to have inherited defective genes.

Scientists from the Institute of Cancer Research in London have now discovered in their study that defective inherited genes are to blame for the development of prostate cancer. This new finding could help in the future to develop individual treatment methods for the disease. For example, genetic tests could determine a predisposition to the disease at an early stage. The doctors published the results of their study in the journal "Journal of Medicine".

Prostate cancer is the third most common fatal cancer
Genetic testing for men with prostate cancer could in the future determine whether they are affected by the dangerous genetic defect and whether special therapy could help them. This could prevent many deaths worldwide. About ten percent of cancer deaths are due to prostate cancer. This makes prostate cancer the third most common fatal cancer. Only lung and colon cancer kill more people every year. Affected people and doctors are always looking for new ways to combat the disease or prevent it from occurring. A study here recently found that regular sex prevents prostate cancer. A preventive measure that most men shouldn't have a problem with.

About twelve percent of men with prostate cancer suffer from an inherited gene mutation
There are several factors that influence whether we develop prostate cancer or not. For example, a larger waist size increases the risk of prostate cancer. The new study has now found that around twelve percent of men with prostate cancer have an inherited gene mutation that can be assessed as a risk factor. This hereditary BRCA mutation could lead to treatment with new drugs, say the doctors. The British scientist and her colleagues from the United States used a simple saliva test to examine 20 genes that play a role in the development of prostate cancer. About twelve percent of the men tested had an inherited mutation in a DNA repair gene. A mutation of BRCA was found in about five percent of men, the experts add.

Sick people could benefit from precision treatment in the future
Our study showed that a significant proportion of men with advanced prostate cancer were born with DNA repair mutations, explains Professor Johann de Bono from the Institute of Cancer Research. In these men with advanced prostate cancer, a genetic test could identify the existing mutation. The sufferers could then benefit from special precision treatment, adds Professor de Bono. Such men should then use drugs such as PARP inhibitors to fight cancer, the scientists explain.

People with advanced prostate cancer often have mutated DNA repair genes
Mutant DNA repair genes were found to be more than four times more common in men with advanced prostate cancer than in the general population, the researchers say. These genes were also found to be more than twice as common in men with advanced prostate cancer than in those with localized prostate cancer, the experts explain. They are therefore to be assessed as a clear risk factor for the disease. (as)

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Video: Genetics in Prostate Cancer: Identification of Inherited Prostate Cancer Risk (August 2021).